Nanomedicines for Parkinson Disease: Current Status and Future Perspective
نویسندگان
چکیده
Parkinson disease (PD) is the second most common progressive neurodegenerative disorder due to loss neurons in SubstantiaNigra pars compacta. A number of medical and surgical treatments are currently available but the beneficial effects wear off with long term use and many native therapies have severe side effects. Hence novel therapeutic strategies continue to be in the developmental demand. Nanomedicine is an important medical application in Nanotechnology which shows promising future in drug delivery system in Parkinson disease. This review gives a glimpse about current treatment for PD and discuss about the Nano-particle based drug delivery which evades Blood-Brain Barrier. BBB stands as a gateway for drug targeting in the central nervous system. Various potential nanoparticles and nanosystems based therapies are explored and benefits are heaved out. Further with a set of well regulated guidelines, it would allow nanotechnology to be used within medicine safely and people could benefit from its attributes.
منابع مشابه
Current Diagnostic Status of Pheochromocytomaand Future Perspective: A Mini Review
Pheochromocytomas (PCCs) are rare neuroendocrine tumors. The current diagnostic tools are based on biochemistry and histopathology results, but heterogeneity of diagnostic markers, signs and symptoms of PCCs bring a lot of difficulties for these two current methods. Unfortunately microscopic understanding of PCCs is not adequate for its confident prognosis and management. There are data linking...
متن کاملP165: Therapeutic Potentials of Stem-Cell-Based Therapy for Parkinson\'s Disease; Current Status of Human Endometrium-Derived Mesenchymal Stem Cells
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. It is expected to impose an increasing economic and social burden on human populations. The motor symptoms of PD are well known, including age-dependent uncontrollable resting tremor, bradykinesia, rigidity, posture instability. In the non-motor symptoms, cognitive changes, d...
متن کاملExosomes: Future Perspective in Neurodegenerative Diseases
Neurodegeneration is a progressive and irreversible loss of neuronal cells in specific regions of the brain. Alzheimer Diseases (AD) Parkinson Disease (PD) are the most common forms of neurodegenerative diseases in older people. Exosomes are extracellular nanovesicles that have a key role in physiological processes such as intercellular communication, cell migration, angiogenesis, and anti-tumo...
متن کاملClosed- and Open-loop Deep Brain Stimulation: Methods, Challenges, Current and Future Aspects
Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required ...
متن کاملNanomedicines as cancer therapeutics: current status.
As of 21st century, cancer is arguably the most complex and challenging disease known to mankind and an inevitable public health concern of this millennium. Nanotechnology, suitably amalgamated with cancer research, has ushered an era of highly personalized and safer medicines which can improve cancer diagnosis and therapy. A wide variety of nanomedicines are currently under investigation, incl...
متن کامل